J Mol Med 2005, 15:401?16. Iwata N, Okazaki M, Kasahara C, Kamiuchi S, Suzuki F, Iizuka H, Hibino Y: Protective effects of a water-soluble extract from culture medium of ganoderma lucidum mycelia against neuronal damage just after cerebral ischemia/reperfusion in diabetic rats. J Jpn Soc Nutr Meals Sci 2008, 61:119?27. Okazaki M, Iwata N, Horiuchi S, Kamiuchi S, Suzuki F, Iizuka H, Hibino Y: Protective effects of a water-soluble extract from culture medium of ganoderma lucidum mycelia against neuronal harm following hypoxia-ischemia in mice. Jpn J Compl Altern Med 2008, 5:153?62. Porsolt RD, Anton G, Blavet N, Jalfre M: Behavioural despair in rats: a brand new model sensitive to antidepressant therapies. Eur J Pharmacol 1978, 47:379?91. Detke MJ, Rickels M, Lucki I: Active behaviors inside the rat forced swimming test differentially made by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl) 1995, 121:66?2. Yamaguchi T, Tsujimatsu A, Kumamoto H, Izumi T, Ohmura Y, Yoshida T, Yoshioka M: Anxiolytic effects of yokukansan, a traditional Japanese medicine, by means of serotonin 5-HT1A receptors on anxiety-related behaviors in rats seasoned aversive tension.5-Amino-3-methylindazole Order J Ethnopharmacol 2012, 143:533?39.Price of (R)-SITCP Bertoglio LJ, Joca SRL, Guimar s FS: Additional proof that anxiousness and memory are regionally dissociated within the hippocampus.PMID:22664133 Behav Brain Res 2006, 175:183?88. Fanselow MS: Conditioned and unconditional components of post-shock freezing. Pavlov J Biol Sci 1973, 15:177?82. Rojas Corrales MO, Gibert Rahola J, Mico JA: Function of atypical opiates in OCD. Experimental method via the study of 5-HT(2A/C) receptor-mediated behavior. Psychopharmacology (Berl) 2007, 190:221?31. Cryan JF, Valentino RJ, Lucki I: Assessing substrates underlying the behavioral effects of antidepressants making use of the modified rat forced swimming test. Neurosci Biobehav Rev 2005, 29:547?69. Rudy JW, Huff NC, Matus-Amat P: Understanding contextual fear conditioning: insights from a two-process model. Neurosci Biobehav Rev 2004, 28:675?85. Carobrez AP, Bertoglio LJ: Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on. Neurosci Biobehav Rev 2005, 29:1193?205. Fanselow MS, Helmstetter FJ: Conditional analgesia, defensive freezing, and benzodiazepines. Behav Neurosci 1988, 102:233?43. Hashimoto S, Inoue T, Koyama T: Effects of conditioned fear strain on serotonin neurotransmission and freezing behavior in rats. Eur J Pharmacol 1999, 378:23?0. Pellow S, Chopin P, File SE, Briley M: Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety inside the rat. J Neurosci Procedures 1985, 14:149?67. Handley SL, McBlane JW, Critchley MA, Njung EK: Many serotonin mechanisms in animal models of anxiety: environmental, emotional and cognitive aspects. Behav Brain Res 1993, 58:203?ten. Griebel G, Rodgers RJ, Perrault G, Sanger DJ: Risk assessment behaviour: evaluation of utility in the study of 5-HT-related drugs within the rat elevated plus-maze test. Pharmacol Biochem Behav 1997, 57:817?27. Griebel G, Perrault G, Sanger DJ: A comparative study of the effects of selective and non-selective 5-HT2 receptor subtype antagonists in rat and mouse models of anxiety. Neuropharmacology 1997, 36:793?02. Nic Dhonnchadha BA, Bourin M, Hasco M: Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiousness. Behav Brain Res 2003, 140:203?14. Corne SJ, Pickering RW, Warner BT: A system for assessing the effects of drugs around the c.