Of free radicals formed by the cyclic oxidation-reduction reactions of the compound in tissues.[4] The symptoms right after ingestion are burning sensation within the mouth, throat, chest, upper abdomen, nausea, vomiting, abdominal discomfort and diarrhea. These gastrointestinal symptoms settle after 2-3 days in the event the patient survives. Ulceration of the mouth, acute renal failure and jaundice may follow a number of days later. The early or delayed look of respiratory distress or failure is one of the characteristic function with the condition.[5] Frequent symptoms of central nervous system (CNS) andAddress for correspondence: Dr. Girish Thunga, Division of Pharmacy Practice, Manipal college of Pharmaceutical Sciences,Manipal – 576 119, Karnataka, India. E-mail: girishthunga77@gmailToxicology International May-Aug 2014 / Vol-21 / Issue-Cherukuri, et al.: Management of herbicide poisoningother systems include things like giddiness, headache, fever, myalgia, lethargy and coma. High fatality is seen in these situations which are mostly resulting from its inherent toxicity and lack of productive treatment. For treatment of these poisoning there are no broadly accepted recommendations.[6] To prevent systemic toxicity resulting from intoxication of those chemical substances instant remedy is essential. In case of ingestion of herbicides like paraquat and glyphospate gastric lavage or whole-gut irrigation employing adsorbents which include Fuller’s earth, bentonite or activated charcoal is advisable.[7] Glyphosate is an a non-selective herbicide. The mechanism by which glyphosate causes toxicity is difficult because of its composition. Typical symptoms of this poisoning consist of gastrointestinal corrosive effects with mouth and throat, epigastric pain and dysphagia. In severe cases, impaired consciousness, arrhythmias, pulmonary edema, shock, renal failure requiring hemodialysis, hyperkalemia and metabolic acidosis are also seen. There’s a sensible relationship among the level of compound ingested plus the effects caused by it.Formula of 2,4-Dimethyl-1H-pyrrole [8] There’s no certain antidote for glyphosate and remedy is primarily supportive or activated charcoal and gastric lavage may be regarded in individuals who are admitted within 1 right after ingestion of poison.2-Bromo-6-(difluoromethoxy)pyridine Order [9]intentional (95 ). The median pre-hospitalization period was found to become three.50 (9.25) hrs. The clinical qualities of herbicide poisoning sufferers primarily includes incidence of vomiting 41 (68.three ), oral ulcers 19 (31.7 ), throat discomfort 16 (26.7 ), abdominal pain 14 (23.3 ), dysphagia 10 (16.7 ) and dyspnea 6 (10.0 ). Among the study population, 6.7 (n = four) of patients had psychiatric illness. Table 1 presents the basic demographic specifics of paraquat poisoning sufferers.PMID:23600560 Unique herbicide compounds consumed are paraquat 47 (78.three ) and glyphosate 13 (21.7 ). Herbicide compounds consumed by the sufferers are offered in Table two. Among the study population majority of them have been students n = 15 (25.0 )) followed by farmers (n = 12 (20.0 ). Details are given within the Table three. Amongst the various treatment approaches majority with the individuals 22 (36.7 ) received gastric lavage and 16 (26.7 ) sufferers received activated charcoal at initial stage of therapy. Among 60, 30 (50.0 ) patients received N-acetylcysteine (NAC), 23 (38.3 ) patients received steroids, furosemide16 (26.7 ), vitaminC15 (25.0 ), cyclophosphamide 13 (21.7 ) and Vitamin E11 (18.three ). A total of 16 (26.7 ) sufferers underwent hemodialysis and Table 1: Demographical and clinical characteristics of herbicide poisoningPatient’s d.